Effect of 15-deoxyspergualin on experimental organ transplantation.
نویسندگان
چکیده
DSPG had a definite but relatively feeble immunosuppressive effect in rats undergoing heterotopic heart transplantation and in dogs after renal transplantation. The drug was toxic in both species, although less so in rats. In dogs, synergistic interactions with cyclosporine and steroids were not evident.
منابع مشابه
Down-regulation of xenophile antibodies by 15-deoxyspergualin in an experimental animal model.
THE SUCCESS of clinical allogeneic organ transplantation has led to a shortage of human organ donors. A solution to this increasing problem is the use of donor organs from outside the human species; Since nonhuman primates are not available in sufficient numbers, are too expensive to breed and keep, and their use is limited by ethical concern, they are very unlikely candidates for xenotransplan...
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THE SUBSTANCE (±)-15-deoxyspergualin (15-DS) is a derivative of spergualin, a guanidinic-like structure. Its isolation from Bacillus /aterosporus and antitumor activity was described by Iwasawa et al. 1 The substance was shown to be effective in experimental transplantation models with pancreas islet cells, heart, and kidney. • Especially with kidney antigen, specific nonreactivity was achieved...
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Newer anti-proliferative drugs Deoxyspergualin is a novel anti-proliferative drug derived from bacillus laterosporus that suppresses lymphocyte and macrophage function and impairs neutrophil production (1). Studies in refractory ANCA-associated vasculitis and crescentic glomerulonephritis have demonstrated useful efficacy and in a murine model of spontaneous vasculitis, deoxyspergualin was supe...
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The immunological barrier remains the major obstacle to the widespread use of transplantation as a replacement therapy for terminal organ failure. Since the first successful renal transplant, performed by Hume et al. (1952), there has been an elusive search for agents that can render the immune mechanism unresponsive to the specific alloantigen stimulus of the engrafted organ, while sparing non...
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The immunosuppressive activity of spergualin analogues, 15-deoxyspergualin and N-30, is presented. These compounds suppressed antibody formation and establishment of delayedtype hypersensitivity to sheep red blood cells (SRBC) in mice. Amongspergualin, 15-deoxyspergualin, and N-30, 1 5-deoxyspergualin was most effective in suppressing immuneresponses. It suppressed antibody formation against SR...
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عنوان ژورنال:
- Transplantation proceedings
دوره 20 1 Suppl 1 شماره
صفحات -
تاریخ انتشار 1988